Prediction of manifest Huntington's disease with clinical and imaging measures: a prospective observational study.

ABSTRACT:

Background

Although the association between cytosine-adenine-guanine (CAG) repeat length and age at onset of Huntington's disease is well known, improved prediction of onset would be advantageous for clinical trial design and prognostic counselling. We compared various measures for tracking progression and predicting conversion to manifest Huntington's disease.

Methods

In this prospective observational study, we assessed the ability of 40 measures in five domains (motor, cognitive, psychiatric, functional, and imaging) to predict time to motor diagnosis of Huntington's disease, accounting for CAG repeat length, age, and the interaction of CAG repeat length and age. Eligible participants were individuals from the PREDICT-HD study (from 33 centres in six countries [USA, Canada

SUBMITTER: Paulsen JS 

PROVIDER: S-EPMC4373455 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature