Influence of lung function on course of disease and response to antibiotic therapy in adult primary care patients with acute cough: a post hoc analysis of patients enrolled in a prospective multicentre study.

ABSTRACT:

Background

In acute cough patients, impaired lung function as present in chronic lung conditions like asthma and chronic obstructive pulmonary disease (COPD) are often thought to negatively influence course of disease, but clear evidence is lacking.

Aims

To investigate the influence of lung function abnormalities on course of disease and response to antibiotic therapy in primary care patients with acute cough.

Methods

A total of 3,104 patients with acute cough (⩽28 days) were included in a prospective observational study with a within-nested trial, of which 2,427 underwent spirometry 28-35 days after inclusion. Influence of the lung function abnormalities fixed obstruction (forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio <0.7) and bronchodilat

SUBMITTER: van Erp N 

PROVIDER: S-EPMC4373460 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature