Histone deacetylase inhibition enhances tissue plasminogen activator release capacity in atherosclerotic man.

ABSTRACT:

Unlabelled

The expression of the tissue plasminogen activator (t-PA) gene appears to be under epigenetic control and can be affected by histone deacetylation inhibition. The study aimed to test if histone deacetalyase inhibitor treatment lead to increased t-PA release or reduced exhaustion in t-PA release in response to stimulation, as well as change in plasminogen activator inhibitor-1 (PAI-1) in subjects with coronary disease. In this clinical study, 16 post-myocardial infarction subjects, the perfused forearm model was used with isoprenaline provocation during 20 minutes, to stimulate local t-PA release. Each subject was measured twice on the same day (repeated stimuli sequences) as well as on two different occasions, without treatment and after four weeks of treatment with valp

SUBMITTER: Svennerholm K 

PROVIDER: S-EPMC4373842 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature