Lectin complement protein Collectin 11 (CL-K1) and susceptibility to urinary schistosomiasis.

ABSTRACT:

Background

Urinary Schistosomiasis is a neglected tropical disease endemic in many sub Saharan -African countries. Collectin Kidney 1 (CL-K1, encoded by COLEC11 on chromosome 2p25.3), a member of the vertebrate C-type lectin super family, has recently been identified as pattern-recognition molecule (PRR) of the lectin complement pathway. CL-K1 is preferentially expressed in the kidneys, but also in other organs and it is considered to play a role in host defense to some infectious agents. Schistosome teguments are fucosylated and CL-K1 has, through its collagen-like domain, a high binding affinity to fucose.

Methodology/principal findings

We utilized a Nigerian study group consisting of 167 Schistosoma haematobium infected individuals and 186 matched healthy subjects, and in

SUBMITTER: Antony JS 

PROVIDER: S-EPMC4373859 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature