Antigenic properties of the human immunodeficiency virus envelope glycoprotein gp120 on virions bound to target cells.

ABSTRACT: The HIV-1 envelope glycoprotein, gp120, undergoes multiple molecular interactions and structural rearrangements during the course of host cell attachment and viral entry, which are being increasingly defined at the atomic level using isolated proteins. In comparison, antigenic markers of these dynamic changes are essentially unknown for single HIV-1 particles bound to target cells. Such markers should indicate how neutralizing and/or non-neutralizing antibodies might interdict infection by either blocking infection or sensitizing host cells for elimination by Fc-mediated effector function. Here we address this deficit by imaging fluorescently labeled CCR5-tropic HIV-1 pseudoviruses using confocal and superresolution microscopy to track the exposure of neutralizing and non-neutralizing epit

SUBMITTER: Mengistu M 

PROVIDER: S-EPMC4373872 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature