Antibacterial properties and atomic resolution X-ray complex crystal structure of a ruthenocene conjugated β-lactam antibiotic.

ABSTRACT: We have determined a 1.18 Å resolution X-ray crystal structure of a novel ruthenocenyle-6-aminopenicillinic acid in complex with CTX-M β-lactamase, showing unprecedented details of interactions between ruthenocene and protein. As the first product complex with an intact catalytic serine, the structure also offers insights into β-lactamase catalysis and inhibitor design.

SUBMITTER: Lewandowski EM 

PROVIDER: S-EPMC4374039 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature