Neurofibromatosis-related tumors: emerging biology and therapies.

ABSTRACT:

Purpose of review

Over the past decade, substantial insight into the biological function of the tumor suppressors neurofibromin (NF1) and Merlin (NF2) has been gained. The purpose of this review is to highlight some of the major advances in our understanding of the biology of neurofibromatosis type 1 (NF1) and neurofibromatosis type 2 (NF2) as they relate to the development of novel therapies for these disorders.

Recent findings

The development of increasingly sophisticated preclinical models over the recent years has provided the platform from which to rationally develop molecular targeted therapies for both NF1 and NF2-related tumors, such as within the Department of Defense-sponsored Neurofibromatosis Clinical Trials Consortium.

Summary

Clinical trials with molecul

SUBMITTER: Karajannis MA 

PROVIDER: S-EPMC4374132 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature