RANK-ligand (RANKL) expression in young breast cancer patients and during pregnancy.

ABSTRACT:

Introduction

RANKL is important in mammary gland development during pregnancy and mediates the initiation and progression of progesterone-induced breast cancer. No clinical data are available on the effect of pregnancy on RANK/RANKL expression in young breast cancer patients.

Methods

We used our previously published dataset of 65 pregnant and 130 matched young breast cancer patients with full clinical, pathological, and survival information. 85% of patients had available transcriptomic data as well. RANK/RANKL expression by immunohistochemistry using H-score on the primary tumor and adjacent normal tissue was performed. We examined the difference in expression of RANK/RANKL between pregnant and non-pregnant patients and their association with clinicopathological features and

SUBMITTER: Azim HA 

PROVIDER: S-EPMC4374174 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature