Serum resistin and glomerular filtration rate in patients with type 2 diabetes.

ABSTRACT:

Background

High serum levels of the pro-inflammatory adipokine resistin have been associated with decreased renal function in the general population. The goal of this study was to investigate whether such association is also present among diabetic subjects, who are at increased risk of renal function loss.

Methods

The cross-sectional association between serum resistin levels and estimated glomerular filtration rate (eGFR) was investigated in 1,560 type 2 diabetic (T2D) patients of European ancestry comprised in two different cohorts: 762 patients from San Giovanni Rotondo (SGR; Italy) and 798 patients from Boston (US).

Results

Serum resistin was inversely associated with eGFR in SGR [β (SE) for one SD of resistin increment = -1.01 (0.70) ml/min/1.73 m(2), p = 0.019] a

SUBMITTER: Moreno LO 

PROVIDER: S-EPMC4374786 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature