Intravenous therapy duration and outcomes in melioidosis: a new treatment paradigm.

ABSTRACT:

Background

International melioidosis treatment guidelines recommend a minimum 10 to 14 days' intravenous antibiotic therapy (intensive phase), followed by 3 to 6 months' oral therapy (eradication phase). This approach is associated with rates of relapse, defined as recurrence following the eradication phase, that can exceed 5%. Rates of recrudescence, defined as recurrence during the eradication phase, have not previously been reported. In response to low eradication phase completion rates in Australia, a local guideline has evolved over the last ten years recommending a longer minimum intensive phase duration for many cases of melioidosis.

Methodology/ principal findings

This retrospective cohort study reviews antibiotic duration for the first episode of care for all patien

SUBMITTER: Pitman MC 

PROVIDER: S-EPMC4374799 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature