Compartmentalized replication of R5 T cell-tropic HIV-1 in the central nervous system early in the course of infection.

ABSTRACT: Compartmentalized HIV-1 replication within the central nervous system (CNS) likely provides a foundation for neurocognitive impairment and a potentially important tissue reservoir. The timing of emergence and character of this local CNS replication has not been defined in a population of subjects. We examined the frequency of elevated cerebrospinal fluid (CSF) HIV-1 RNA concentration, the nature of CSF viral populations compared to the blood, and the presence of a cellular inflammatory response (with the potential to bring infected cells into the CNS) using paired CSF and blood samples obtained over the first two years of infection from 72 ART-naïve subjects. Using single genome amplification (SGA) and phylodynamics analysis of full-length env sequences, we compared CSF and blood viral pop

SUBMITTER: Sturdevant CB 

PROVIDER: S-EPMC4374811 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature