A genomic portrait of haplotype diversity and signatures of selection in indigenous southern African populations.

ABSTRACT: We report a study of genome-wide, dense SNP (∼ 900K) and copy number polymorphism data of indigenous southern Africans. We demonstrate the genetic contribution to southern and eastern African populations, which involved admixture between indigenous San, Niger-Congo-speaking and populations of Eurasian ancestry. This finding illustrates the need to account for stratification in genome-wide association studies, and that admixture mapping would likely be a successful approach in these populations. We developed a strategy to detect the signature of selection prior to and following putative admixture events. Several genomic regions show an unusual excess of Niger-Kordofanian, and unusual deficiency of both San and Eurasian ancestry, which were considered the footprints of selection after popula

SUBMITTER: Chimusa ER 

PROVIDER: S-EPMC4374865 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature