Amniotic fluid stem cells prevent β-cell injury.

ABSTRACT:

Background aims

The contribution of amniotic fluid stem cells (AFSC) to tissue protection and regeneration in models of acute and chronic kidney injuries and lung failure has been shown in recent years. In the present study, we used a chemically induced mouse model of type 1 diabetes to determine whether AFSC could play a role in modulating β-cell injury and restoring β-cell function.

Methods

Streptozotocin-induced diabetic mice were given intracardial injection of AFSC; morphological and physiological parameters and gene expression profile for the insulin pathway were evaluated after cell transplantation.

Results

AFSC injection resulted in protection from β-cell damage and increased β-cell regeneration in a subset of mice as indicated by glucose and insulin levels, i

SUBMITTER: Villani V 

PROVIDER: S-EPMC4374982 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature