Volatile organic compounds in bile for early diagnosis of cholangiocarcinoma in patients with primary sclerosing cholangitis: a pilot study.

ABSTRACT:

Background

The diagnosis of cholangiocarcinoma (CCA) in patients with primary sclerosing cholangitis (PSC) is particularly difficult. The role of volatile organic compounds (VOCs) for diagnosis of CCA in patients with PSC is not known.

Objective

Our aim was to identify potential VOCs in the headspaces (gas above the sample) in bile that may predict CCA in patients with PSC.

Design

Prospective cross-sectional study.

Setting

Referral center.

Patients

A total of 32 patients undergoing ERCP for PSC and for CCA complicating PSC.

Interventions

ERCP, bile aspiration.

Main outcome measurements

Selected ion flow tube mass spectrometry was used to analyze the concentration of 22 prevalent VOCs in bile samples. Logistic regression analysis was perform

SUBMITTER: Navaneethan U 

PROVIDER: S-EPMC4375033 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature