Structural libraries of protein models for multiple species to understand evolution of the renin-angiotensin system.

ABSTRACT: The details of protein pathways at a structural level provides a bridge between genetics/molecular biology and physiology. The renin-angiotensin system is involved in many physiological pathways with informative structural details in multiple components. Few studies have been performed assessing structural knowledge across the system. This assessment allows use of bioinformatics tools to fill in missing structural voids. In this paper we detail known structures of the renin-angiotensin system and use computational approaches to estimate and model components that do not have their protein structures defined. With the subsequent large library of protein structures, we then created a species specific protein library for human, mouse, rat, bovine, zebrafish, and chicken for the system. The rat

SUBMITTER: Prokop JW 

PROVIDER: S-EPMC4375088 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature