Cardiovascular comorbidities and survival of lung cancer patients: Medicare data based analysis.

ABSTRACT:

Objectives

To evaluate the role of cardiovascular disease (CVD) comorbidity in survival of patients with non-small cell lung cancer (NSCLC).

Materials and methods

The impact of seven CVDs (at the time of NSCLC diagnosis and during subsequent follow-up) on overall survival was studied for NSCLC patients aged 65+ years using the Surveillance, Epidemiology, and End Results data linked to the U.S. Medicare data, cancer stage- and treatment-specific. Cox regression was applied to evaluate death hazard ratios of CVDs in univariable and multivariable analyses (controlling by age, TNM statuses, and 78 non-CVD comorbidities) and to investigate the effects of 128 different combinations of CVDs on patients' survival.

Results

Overall, 95,167 patients with stage I (n=29,836, 31.4%

SUBMITTER: Kravchenko J 

PROVIDER: S-EPMC4375130 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature