Lymphovascular invasion and histologic grade are associated with specific genomic profiles in invasive carcinomas of the breast.

ABSTRACT: Lymphovascular invasion (LVI) and histologic grade are clinical parameters of high prognostic value in breast cancer and indicate the level of tumor aggressiveness. Many studies have focused on the association of breast cancer subtypes with gene expression and chromosomal profiles, but considerably less genomic information is available regarding traditional prognostic factors such as histologic grade and LVI. We studied by array-CGH a group of 57 invasive ductal carcinomas of the breast to outline the DNA copy number aberration (CNA) profile linked to high histologic grades and LVI. Selected CNAs were validated using real-time quantitative PCR (qPCR). Furthermore, gene expression analysis was performed in a subset of 32 of these tumors, and findings were integrated with array-CGH data. Our

SUBMITTER: Fidalgo F 

PROVIDER: S-EPMC4375298 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature