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Epidemiological and viral genomic sequence analysis of the 2014 ebola outbreak reveals clustered transmission.

ABSTRACT: Using Ebolavirus genomic and epidemiological data, we conducted the first joint analysis in which both data types were used to fit dynamic transmission models for an ongoing outbreak. Our results indicate that transmission is clustered, highlighting a potential bias in medical demand forecasts, and provide the first empirical estimate of underreporting.

SUBMITTER: Scarpino SV 

PROVIDER: S-EPMC4375398 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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Epidemiological and viral genomic sequence analysis of the 2014 ebola outbreak reveals clustered transmission.

Scarpino Samuel V SV   Iamarino Atila A   Wells Chad C   Yamin Dan D   Ndeffo-Mbah Martial M   Wenzel Natasha S NS   Fox Spencer J SJ   Nyenswah Tolbert T   Altice Frederick L FL   Galvani Alison P AP   Meyers Lauren Ancel LA   Townsend Jeffrey P JP  

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20141215 7

Using Ebolavirus genomic and epidemiological data, we conducted the first joint analysis in which both data types were used to fit dynamic transmission models for an ongoing outbreak. Our results indicate that transmission is clustered, highlighting a potential bias in medical demand forecasts, and provide the first empirical estimate of underreporting. ...[more]

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