Dataset Information

Sensory and motor peripheral nerve function and longitudinal changes in quadriceps strength.

ABSTRACT:

Background

Poor peripheral nerve function is common in older adults and may be a risk factor for strength decline, although this has not been assessed longitudinally.

Methods

We assessed whether sensorimotor peripheral nerve function predicts strength longitudinally in 1,830 participants (age = 76.3 ± 2.8, body mass index = 27.2 ± 4.6kg/m(2), strength = 96.3 ± 34.7 Nm, 51.0% female, 34.8% black) from the Health ABC study. Isokinetic quadriceps strength was measured semiannually over 6 years. Peroneal motor nerve conduction amplitude and velocity were recorded. Sensory nerve function was assessed with 10-g and 1.4-g monofilaments and average vibration detection threshold at the toe. Lower-extremity neuropathy symptoms were self-reported.

Results

Worse vibration detection threshold predicted 2.4% lower strength in men and worse motor amplitude and two symptoms predicted 2.5% and 8.1% lower strength, respectively, in women. Initial 10-g monofilament insensitivity predicted 14.2% lower strength and faster strength decline in women and 6.6% lower strength in men (all p < .05).

Conclusion

Poor nerve function predicted lower strength and faster strength decline. Future work should examine interventions aimed at preventing declines in strength in older adults with impaired nerve function.

SUBMITTER: Ward RE

PROVIDER: S-EPMC4375416 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Sensory and motor peripheral nerve function and longitudinal changes in quadriceps strength.

Ward Rachel E RE Boudreau Robert M RM Caserotti Paolo P Harris Tamara B TB Zivkovic Sasa S Goodpaster Bret H BH Satterfield Suzanne S Kritchevsky Stephen S Schwartz Ann V AV Vinik Aaron I AI Cauley Jane A JA Newman Anne B AB Strotmeyer Elsa S ES

The journals of gerontology. Series A, Biological sciences and medical sciences 20141015 4

<h4>Background</h4>Poor peripheral nerve function is common in older adults and may be a risk factor for strength decline, although this has not been assessed longitudinally.<h4>Methods</h4>We assessed whether sensorimotor peripheral nerve function predicts strength longitudinally in 1,830 participants (age = 76.3 ± 2.8, body mass index = 27.2 ± 4.6kg/m(2), strength = 96.3 ± 34.7 Nm, 51.0% female, 34.8% black) from the Health ABC study. Isokinetic quadriceps strength was measured semiannually ov ...[more]

PMID: 25320056

Similar Datasets

Project description:BackgroundDiminished corticospinal excitability is theorized to contribute to poor quadriceps function after anterior cruciate ligament (ACL) reconstruction. Operant conditioning of the motor evoked torque (MEPTORQUE) is a promising approach capable of improving corticospinal excitability. However, it is unknown whether increasing corticospinal excitability can improve quadriceps function after a short-term operant conditioning intervention in patients with reconstructed ACL.HypothesisAfter ACL reconstruction, patients would demonstrate increases in quadriceps strength, voluntary activation, and corticospinal excitability after a 2-week operant conditioning intervention.Study designRandomized controlled clinical trial.Level of evidenceLevel 1.MethodsA total of 22 patients with reconstructed ACL were randomized into 1 of 2 groups: group 1 received 2 weeks of operant conditioning training on the reconstructed leg to improve their transcranial magnetic stimulation (TMS)-elicited MEPTORQUE responses (COND); group 2 received 2 weeks of TMS only (SHAM-COND). Quadriceps strength, voluntary activation, and corticospinal excitability on the reconstructed leg were evaluated before and after the 2-week intervention. Within-session changes in corticospinal excitability were also evaluated during the training sessions.ResultsThe COND group demonstrated a significantly higher within-session percent increase in MEPTORQUE during training compared with the SHAM-COND group, paralleled by a significant increase in corticospinal excitability after the 2-week intervention. In addition, quadriceps strength and voluntary activation improved on the reconstructed leg after the 2-week intervention, regardless of group.ConclusionOperant conditioning training can elicit improvements in corticospinal excitability after ACL reconstruction; however, improvements in quadriceps strength and voluntary activation seem not to be attributed solely to operant upconditioning training.Clinical relevanceOperant conditioning is a promising approach to improve corticospinal excitability after ACL reconstruction. However, optimizing the delivery of operant conditioning protocols by potentially increasing the dosage of operant conditioning and intervening earlier after surgery may be needed to translate these changes to improvements in quadriceps function.

Dataset Information

Sensory and motor peripheral nerve function and longitudinal changes in quadriceps strength.

Background

Methods

Results

Conclusion

Publications

Sensory and motor peripheral nerve function and longitudinal changes in quadriceps strength.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets