Pattern selection by dynamical biochemical signals.

ABSTRACT: The development of multicellular organisms involves cells to decide their fate upon the action of biochemical signals. This decision is often spatiotemporally coordinated such that a spatial pattern arises. The dynamics that drive pattern formation usually involve genetic nonlinear interactions and positive feedback loops. These complex dynamics may enable multiple stable patterns for the same conditions. Under these circumstances, pattern formation in a developing tissue involves a selection process: why is a certain pattern formed and not another stable one? Herein we computationally address this issue in the context of the Notch signaling pathway. We characterize a dynamical mechanism for developmental selection of a specific pattern through spatiotemporal changes of the control paramet

SUBMITTER: Palau-Ortin D 

PROVIDER: S-EPMC4375446 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature