Malignant melanoma in early-treated Parkinson's disease: the NET-PD trial.

ABSTRACT:

Background

The risk for malignant melanoma is higher than expected in Parkinson's disease (PD). The National Institutes of Health (NIH) Exploratory Trials in PD (NET-PD) Long-term Study 1 (LS-1) trial is a contemporary phase 3 study of subjects with early, treated PD. The objective of this work was to assess the incidence of malignant melanoma in a PD cohort.

Methods

Incident melanoma cases were identified from the adverse events log. The expected number of cases was calculated, using the expected incidence rates and the number of person-years.

Results

A total of 618 females and 1119 males were followed for 6452 person-years; 19 new melanoma cases were observed. The expected number was 5.29. The standardized event ratio compared to the general population was 3.6 (95%

SUBMITTER: Constantinescu R 

PROVIDER: S-EPMC4375545 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature