Schizophrenia risk variants modulate white matter volume across the psychosis spectrum: evidence from two independent cohorts.

ABSTRACT: Polygenic risk scores, based on risk variants identified in genome-wide-association-studies (GWAS), explain a considerable portion of the heritability for schizophrenia (SZ) and bipolar disorder (BD). However, little is known about the combined effects of these variants, although polygenic neuroimaging has developed into a powerful tool of translational neuroscience. In this study, we used genome wide significant SZ risk variants to test the predictive capacity of the polygenic model and explored potential associations with white matter volume, a key candidate in imaging phenotype for psychotic disorders. By calculating the combined additive schizophrenia risk of seven SNPs (significant hits from a recent schizophrenia GWAS study), we show that increased additive genetic risk for SZ was as

SUBMITTER: Oertel-Knochel V 

PROVIDER: S-EPMC4375641 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature