Nutrient patterns and brain biomarkers of Alzheimer's disease in cognitively normal individuals.

ABSTRACT:

Objectives

Epidemiological evidence linking diet, one of the most important modifiable lifestyle factors, and risk of Alzheimer's disease (AD) is rapidly increasing. However, there is little or no evidence for a direct association between dietary nutrients and brain biomarkers of AD. This study identifies nutrient patterns associated with major brain AD biomarkers in a cohort of clinically and cognitively normal (NL) individuals at risk for AD.

Design

Cross-sectional study.

Setting

Manhattan (broader area).

Participants

Fifty-two NL individuals (age 54+12 y, 70% women, Clinical Dementia Rating=0, MMSE>27, neuropsychological test performance within norms by age and education) with complete dietary information and cross-sectional, 3D T1-weighted Magnetic Resonanc

SUBMITTER: Berti V 

PROVIDER: S-EPMC4375781 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature