Activation of an endogenous retrovirus-associated long non-coding RNA in human adenocarcinoma.

ABSTRACT:

Background

Long non-coding RNAs (lncRNAs) are emerging as molecules that significantly impact many cellular processes and have been associated with almost every human cancer. Compared to protein-coding genes, lncRNA genes are often associated with transposable elements, particularly with endogenous retroviral elements (ERVs). ERVs can have potentially deleterious effects on genome structure and function, so these elements are typically silenced in normal somatic tissues, albeit with varying efficiency. The aberrant regulation of ERVs associated with lncRNAs (ERV-lncRNAs), coupled with the diverse range of lncRNA functions, creates significant potential for ERV-lncRNAs to impact cancer biology.

Methods

We used RNA-seq analysis to identify and profile the expression of a novel

SUBMITTER: Gibb EA 

PROVIDER: S-EPMC4375928 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature