Obesity genetics in mouse and human: back and forth, and back again.

ABSTRACT: Obesity is a major public health concern. This condition results from a constant and complex interplay between predisposing genes and environmental stimuli. Current attempts to manage obesity have been moderately effective and a better understanding of the etiology of obesity is required for the development of more successful and personalized prevention and treatment options. To that effect, mouse models have been an essential tool in expanding our understanding of obesity, due to the availability of their complete genome sequence, genetically identified and defined strains, various tools for genetic manipulation and the accessibility of target tissues for obesity that are not easily attainable from humans. Our knowledge of monogenic obesity in humans greatly benefited from the mouse obesi

SUBMITTER: Yazdi FT 

PROVIDER: S-EPMC4375971 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature