Predictors of muscle protein synthesis after severe pediatric burns.

ABSTRACT:

Background

Following a major burn, skeletal muscle protein synthesis rate increases but is often insufficient to compensate for massively elevated muscle protein breakdown rates. Given the long-term nature of the pathophysiologic response to burn injury, we hypothesized that muscle protein synthesis rate would be chronically elevated in severely burned children. The objectives of this study were to characterize muscle protein synthesis rate of burned children over a period of 24 months after injury and to identify predictors that influence this response.

Methods

A total of 87 children with 40% or greater total body surface area (TBSA) burned were included. Patients participated in stable isotope infusion studies at 1, 2, and approximately 4 weeks after burn and at 6, 12, and

SUBMITTER: Diaz EC 

PROVIDER: S-EPMC4376006 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature