Increased fibroblast growth factor 21 expression in high-fat diet-sensitive non-human primates (Macaca mulatta).

ABSTRACT:

Objective

Fibroblast growth factor 21 (FGF21) is a metabolic regulator of glucose and lipid metabolism. The physiological role of FGF21 is not yet fully elucidated, however, administration of FGF21 lowers blood glucose in diabetic animals. Moreover, increased levels of FGF21 are found in obese and diabetic rodents and humans compared with lean/non-diabetic controls.

Methods

Adult male rhesus macaque monkeys were chronically maintained on a high-fat diet (HFD) or a standard diet (control, CTR). Plasma levels of FGF21, triglycerides and cholesterol were measured and body weight was record. Glucose-stimulated insulin secretion (GSIS) and glucose clearance was determined during an intravenous glucose tolerance test. Furthermore, expression of FGF21 and its receptors were determi

SUBMITTER: Nygaard EB 

PROVIDER: S-EPMC4376022 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature