A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland.

ABSTRACT: Progesterone drives mammary stem and progenitor cell dynamics through paracrine mechanisms that are currently not well understood. Here, we demonstrate that CXCR4, the receptor for stromal-derived factor 1 (SDF-1; CXC12), is a crucial instructor of hormone-induced mammary stem and progenitor cell function. Progesterone elicits specific changes in the transcriptome of basal and luminal mammary epithelial populations, where CXCL12 and CXCR4 represent a putative ligand-receptor pair. In situ, CXCL12 localizes to progesterone-receptor-positive luminal cells, whereas CXCR4 is induced in both basal and luminal compartments in a progesterone-dependent manner. Pharmacological inhibition of CXCR4 signaling abrogates progesterone-directed expansion of basal (CD24⁺CD49f^hi) and l

SUBMITTER: Shiah YJ 

PROVIDER: S-EPMC4376056 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature