The fate of calcium carbonate nanoparticles administered by oral route: absorption and their interaction with biological matrices.

ABSTRACT:

Background

Orally administered particles rapidly interact with biological fluids containing proteins, enzymes, electrolytes, and other biomolecules to eventually form particles covered by a corona, and this corona potentially affects particle uptake, fate, absorption, distribution, and elimination in vivo. This study explored relationships between the biological interactions of calcium carbonate particles and their biokinetics.

Methods

We examined the effects of food grade calcium carbonates of different particle size (nano [N-Cal] and bulk [B-Cal]: specific surface areas of 15.8 and 0.83 m(2)/g, respectively) on biological interactions in in vitro simulated physiological fluids, ex vivo biofluids, and in vivo in gastrointestinal fluid. Moreover, absorption and tissue distri

SUBMITTER: Lee JA 

PROVIDER: S-EPMC4376267 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature