Metronidazole vaginal gel 1.3% in the treatment of bacterial vaginosis: a dose-ranging study.

ABSTRACT:

Objective

Metronidazole vaginal gel (MVG) 0.75% is a US Food and Drug Administration-approved, 5-day treatment for bacterial vaginosis (BV). This study tested the hypothesis that a shorter treatment course at a higher dose (MVG 1.3%) would yield similar efficacy to 5 days of MVG 0.75%.

Materials and methods

This phase 2, multicenter, randomized, controlled, investigator-blinded, dose-ranging study enrolled women with a clinical diagnosis of BV. Patients were assigned to MVG 1.3% once daily for 1, 3, or 5 days or MVG 0.75% once daily for 5 days. The therapeutic cure rate, requiring clinical and bacteriological cure, at the end-of-study visit was determined for the per-protocol population. A Kaplan-Meier analysis was used to estimate median time-to-symptom resolution.

Resul

SUBMITTER: Chavoustie SE 

PROVIDER: S-EPMC4376277 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature