An integrative approach for modeling and simulation of heterocyst pattern formation in cyanobacteria filaments.

ABSTRACT: Heterocyst differentiation in cyanobacteria filaments is one of the simplest examples of cellular differentiation and pattern formation in multicellular organisms. Despite of the many experimental studies addressing the evolution and sustainment of heterocyst patterns and the knowledge of the genetic circuit underlying the behavior of single cyanobacterium under nitrogen deprivation, there is still a theoretical gap connecting these two macroscopic and microscopic processes. As an attempt to shed light on this issue, here we explore heterocyst differentiation under the paradigm of systems biology. This framework allows us to formulate the essential dynamical ingredients of the genetic circuit of a single cyanobacterium into a set of differential equations describing the time evolution of t

SUBMITTER: Torres-Sanchez A 

PROVIDER: S-EPMC4376521 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature