Dissecting the roles of microRNAs in coronary heart disease via integrative genomic analyses.

ABSTRACT:

Objective

The roles of microRNAs (miRNAs) in coronary heart disease (CHD) have not been well characterized. This study sought to systematically characterize the complex genomic architecture of CHD by integrating whole blood miRNA and mRNA expression with genetic variation in 186 CHD cases and 186 controls.

Approach and results

At false discovery rate <0.2, 15 miRNAs were differentially expressed between CHD cases and controls. To explore regulatory mechanisms, we integrated miRNA and mRNA expression with genome-wide genotype data to investigate miRNA and mRNA associations and relationships of genetic variation with miRNAs. We identified a large number of correlated miRNA-mRNA pairs and genetic loci that seem to regulate miRNA levels. Subsequently, we explored the relationshi

SUBMITTER: Huan T 

PROVIDER: S-EPMC4376567 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature