Early hyperlipidemia promotes endothelial activation via a caspase-1-sirtuin 1 pathway.

ABSTRACT:

Objective

The role of receptors for endogenous metabolic danger signals-associated molecular patterns has been characterized recently as bridging innate immune sensory systems for danger signals-associated molecular patterns to initiation of inflammation in bone marrow-derived cells, such as macrophages. However, it remains unknown whether endothelial cells (ECs), the cell type with the largest numbers and the first vessel cell type exposed to circulating danger signals-associated molecular patterns in the blood, can sense hyperlipidemia. This report determined whether caspase-1 plays a role in ECs in sensing hyperlipidemia and promoting EC activation.

Approach and results

Using biochemical, immunologic, pathological, and bone marrow transplantation methods together with the

SUBMITTER: Yin Y 

PROVIDER: S-EPMC4376583 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature