Sex differences in platelet toll-like receptors and their association with cardiovascular risk factors.

ABSTRACT:

Objective

Platelets contribute to thrombosis, and platelet toll-like receptors (TLRs) are central in pathogen detection, potentially mediating infection-induced vascular occlusion. Using a large community-based cohort study, we sought to examine if platelets express all known TLR transcripts and analyze their association with cardiovascular risk factors.

Approach and results

mRNA levels for TLRs were measured in isolated platelets by high-throughput quantitative reverse transcriptase polymerase chain reaction in 1625 participants (mean age, 66.6±9; 54% women) of the Framingham Heart Study. We measured circulating inflammatory and thrombotic markers (C-reactive protein, interleukin-6, monocyte chemoattractant protein 1, intracellular cell adhesion molecule 1, soluble tumor ne

SUBMITTER: Koupenova M 

PROVIDER: S-EPMC4376646 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature