Estrogen receptor-β ligand treatment after disease onset is neuroprotective in the multiple sclerosis model.

ABSTRACT: Multiple sclerosis (MS) is an autoimmune disease characterized by inflammation and neurodegeneration. Current MS treatments were designed to reduce inflammation in MS rather than directly to prevent neurodegeneration. Estrogen has well-documented neuroprotective effects in a variety of disorders of the CNS, including experimental autoimmune encephalomyelitis (EAE), the most widely used mouse model of MS. Treatment with an estrogen receptor-β (ERβ) ligand is known to ameliorate clinical disease effectively and provide neuroprotection in EAE. However, the protective effects of this ERβ ligand have been demonstrated only when administered prior to disease (prophylactically). Here we tested whether ERβ ligand treatment could provide clinical protection when treatment was initiated after onset

SUBMITTER: Wisdom AJ 

PROVIDER: S-EPMC4376676 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature