Mechanisms of gain control by voltage-gated channels in intrinsically-firing neurons.

ABSTRACT: Gain modulation is a key feature of neural information processing, but underlying mechanisms remain unclear. In single neurons, gain can be measured as the slope of the current-frequency (input-output) relationship over any given range of inputs. While much work has focused on the control of basal firing rates and spike rate adaptation, gain control has been relatively unstudied. Of the limited studies on gain control, some have examined the roles of synaptic noise and passive somatic currents, but the roles of voltage-gated channels present ubiquitously in neurons have been less explored. Here, we systematically examined the relationship between gain and voltage-gated ion channels in a conductance-based, tonically-active, model neuron. Changes in expression (conductance density) of voltag

SUBMITTER: Patel AX 

PROVIDER: S-EPMC4376733 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature