The impact of immunosenescence on humoral immune response variation after influenza A/H1N1 vaccination in older subjects.

ABSTRACT:

Background

Although influenza causes significant morbidity and mortality in the elderly, the factors underlying the reduced vaccine immunogenicity and efficacy in this age group are not completely understood. Age and immunosenescence factors, and their impact on humoral immunity after influenza vaccination, are of growing interest for the development of better vaccines for the elderly.

Methods

We assessed associations between age and immunosenescence markers (T cell receptor rearrangement excision circles - TREC content, peripheral white blood cell telomerase - TERT expression and CD28 expression on T cells) and influenza A/H1N1 vaccine-induced measures of humoral immunity in 106 older subjects at baseline and three timepoints post-vaccination.

Results

TERT activity (

SUBMITTER: Haralambieva IH 

PROVIDER: S-EPMC4376784 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature