Intrapericardial administration of mesenchymal stem cells in a large animal model: a bio-distribution analysis.

ABSTRACT: The appropriate administration route for cardiovascular cell therapy is essential to ensure the viability, proliferative potential, homing capacity and implantation of transferred cells. At the present, the intrapericardial administration of pharmacological agents is considered an efficient method for the treatment of cardiovascular diseases. However, only a few reports have addressed the question whether the intrapericardial delivery of Mesenchymal Stem Cells (MSCs) could be an optimal administration route. This work firstly aimed to analyze the pericardial fluid as a cell-delivery vehicle. Moreover, the in vivo biodistribution pattern of intrapericardially administered MSCs was evaluated in a clinically relevant large animal model. Our in vitro results firstly showed that, MSCs viability

SUBMITTER: Blazquez R 

PROVIDER: S-EPMC4376786 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature