Association of mild kidney dysfunction with silent brain lesions in neurologically normal subjects.

ABSTRACT:

Background

Chronic kidney disease (CKD) has been closely associated with stroke. Although a large number of studies reported the relationship between CKD and different types of asymptomatic brain lesions, few comprehensive analyses have been performed for all types of silent brain lesions.

Methods

We performed a cross-sectional study involving 1,937 neurologically normal subjects (mean age 59.4 years). Mild CKD was defined as an estimated glomerular filtration rate between 30 and 60 ml/min/1.73 m(2) or positive proteinuria.

Results

The prevalence of mild CKD was 8.7%. Univariate analysis revealed an association between CKD and all silent brain lesions, including silent brain infarction, periventricular hyperintensity, subcortical white matter lesion, and microbleeds,

SUBMITTER: Toyoda G 

PROVIDER: S-EPMC4376920 | biostudies-literature | 2015 Jan-Apr

REPOSITORIES: biostudies-literature