Association between DNA Methylation of the BDNF Promoter Region and Clinical Presentation in Alzheimer's Disease.

ABSTRACT:

Background/aims

In the present study, we examined whether DNA methylation of the brain-derived neurotrophic factor (BDNF) promoter is associated with the manifestation and clinical presentation of Alzheimer's disease (AD).

Methods

Of 20 patients with AD and 20 age-matched normal controls (NCs), the DNA methylation of the BDNF promoter (measured using peripheral blood samples) was completely analyzed in 12 patients with AD and 6 NCs. The resulting methylation levels were compared statistically. Next, we investigated the correlation between the DNA methylation levels and the clinical presentation of AD.

Results

The total methylation ratio (in %) of the 20 CpG sites was significantly higher in the AD patients (5.08 ± 5.52%) than in the NCs (2.09 ± 0.81%; p < 0.05). Of th

SUBMITTER: Nagata T 

PROVIDER: S-EPMC4376924 | biostudies-literature | 2015 Jan-Apr

REPOSITORIES: biostudies-literature