A biased competition theory of cytotoxic T lymphocyte interaction with tumor nodules.

ABSTRACT: The dynamics of the interaction between Cytotoxic T Lymphocytes (CTL) and tumor cells has been addressed in depth, in particular using numerical simulations. However, stochastic mathematical models that take into account the competitive interaction between CTL and tumors undergoing immunoediting, a process of tumor cell escape from immunesurveillance, are presently missing. Here, we introduce a stochastic dynamical particle interaction model based on experimentally measured parameters that allows to describe CTL function during immunoediting. The model describes the competitive interaction between CTL and melanoma cell nodules and allows temporal and two-dimensional spatial progression. The model is designed to provide probabilistic estimates of tumor eradication through numerical simulati

SUBMITTER: Christophe C 

PROVIDER: S-EPMC4376944 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature