Correlation Between Hepatitis B G1896A Precore Mutations and HBeAg in Chronic HBV Patients.

ABSTRACT:

Background

Hepatitis B virus (HBV) infection is an important health concern worldwide, with critical outcomes. Hepatitis B e antigen (HBeAg) negative chronic hepatitis B is frequently caused by a mutation (G1896A) in the hepatitis B virus (HBV) precore (PC) reading frame, which creates a stop codon, causing premature termination of the HBe protein.

Objectives

This study aimed to investigate the G1896A PC mutation and its effect on HBeAg detection in chronic HBV patients.

Patients and methods

In this study, 120 chronic HBV patients neither vaccinated or who had benefited from immunoglobulin therapy, were recruited. The HBV-DNA was extracted from plasma and polymerase chain reaction (PCR) was performed. Positive PCR products were subjected to automated sequencing. The H

SUBMITTER: Zhand S 

PROVIDER: S-EPMC4376977 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature