Characterization of the β-barrel assembly machine accessory lipoproteins from Borrelia burgdorferi.

ABSTRACT:

Background

Like all diderm bacteria studied to date, Borrelia burgdorferi possesses a β-barrel assembly machine (BAM) complex. The bacterial BAM complexes characterized thus far consist of an essential integral outer membrane protein designated BamA and one or more accessory proteins. The accessory proteins are typically lipid-modified proteins anchored to the inner leaflet of the outer membrane through their lipid moieties. We previously identified and characterized the B. burgdorferi BamA protein in detail and more recently identified two lipoproteins encoded by open reading frames bb0324 and bb0028 that associate with the borrelial BamA protein. The role(s) of the BAM accessory lipoproteins in B. burgdorferi is currently unknown.

Results

Structural modeling of B. burgdorf

SUBMITTER: Dunn JP 

PROVIDER: S-EPMC4377024 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature