Regulation of molecular pathways in ischemia-reperfusion injury after liver transplantation.

ABSTRACT:

Background

Ischemia-reperfusion (I/R) injury is a multifactorial phenomenon that occurs during the transplant event and frequently compromises early graft function after liver transplantation (LT). Current comprehension of molecular mechanisms and regulation processes of I/R injury lacks clarity. MicroRNA (miRNA) regulation results critical in several biological processes.

Methods

This study evaluated gene expression and miRNA expression profiles using microarrays in 34 graft biopsies collected at preimplantation (L1) and at 90 min postreperfusion (L2) from consecutives deceased-donor LT recipients. miRNA profiles were first analyzed. Data integration analysis (gene expression/miRNA expression) aimed to identify potential target genes for each identified miRNA from the L1/L2

SUBMITTER: Gehrau RC 

PROVIDER: S-EPMC4377108 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature