An index to predict ribavirin-induced anemia in asian patients with chronic genotype 1 hepatitis C.

ABSTRACT:

Background

Single-nucleotide polymorphisms (SNP) in the inosine triphosphate pyrophosphatase (ITPA) gene correlate with ribavirin (RBV)-induced anemia in patients with chronic hepatitis C (CHC) receiving combination therapy. Managing anemia is an early priority in the treatment process.

Objectives

The aim was to develop a predictive index based on ITPA SNP status to identify CHC patients at risk of anemia.

Patients and methods

A total of 418 eligible East Asian patients diagnosed with CHC genotype 1 (G1) received combination therapy in this study. Participant DNA was genotyped for a functional ITPA SNP (C/C, A/A or C/A) on chromosome 20 at rs1127354. A predictive index was constructed by incorporating independent factors identified for severe anemia events (hemoglobin

SUBMITTER: Chen SH 

PROVIDER: S-EPMC4377223 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature