Blood gene expression profiles suggest altered immune function associated with symptoms of generalized anxiety disorder.

ABSTRACT: Prospective epidemiological studies found that generalized anxiety disorder (GAD) can impair immune function and increase risk for cardiovascular disease or events. Mechanisms underlying the physiological reverberations of anxiety, however, are still elusive. Hence, we aimed to investigate molecular processes mediating effects of anxiety on physical health using blood gene expression profiles of 336 community participants (157 anxious and 179 control). We examined genome-wide differential gene expression in anxiety, as well as associations between nine major modules of co-regulated transcripts in blood gene expression and anxiety. No significant differential expression was observed in women, but 631 genes were differentially expressed between anxious and control men at the false discovery

SUBMITTER: Wingo AP 

PROVIDER: S-EPMC4377320 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature