Supplementation with complex milk lipids during brain development promotes neuroplasticity without altering myelination or vascular density.

ABSTRACT:

Background

Supplementation with complex milk lipids (CML) during postnatal brain development has been shown to improve spatial reference learning in rats.

Objective

The current study examined histo-biological changes in the brain following CML supplementation and their relationship to the observed improvements in memory.

Design

The study used the brain tissues from the rats (male Wistar, 80 days of age) after supplementing with either CML or vehicle during postnatal day 10-80. Immunohistochemical staining of synaptophysin, glutamate receptor-1, myelin basic protein, isolectin B-4, and glial fibrillary acidic protein was performed. The average area and the density of the staining and the numbers of astrocytes and capillaries were assessed and analysed.

Results

C

SUBMITTER: Guillermo RB 

PROVIDER: S-EPMC4377325 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature