TNF, IL12B, and IFNG Gene Polymorphisms in Serbian Patients with Psoriasis.

ABSTRACT:

Background

Psoriasis is a common chronic inflammatory skin disease with a strong genetic basis. Cytokines such as tumor necrosis factor alpha (TNF-α), interleukins (ILs) such are IL-12 and IL-23, and interferon gamma (IFN-γ) are released from various inflammatory and resident cells, and have been implicated in the initiation/maintenance of inflammation. Certain alleles of the aforementioned cytokines may be associated with disease susceptibility/severity.

Objective

To investigate the association of three common functional gene polymorphisms, namely TNF -308 G/A (rs1800629), IL12B (encoding the p40 subunit of IL-12/23) +1188 A/C (rs3212227), and IFNG +874 T/A (rs2430561) with psoriasis development and severity in Serbian patients.

Methods

We genotyped 130 patients with

SUBMITTER: Popadic S 

PROVIDER: S-EPMC4377400 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature