Spatial training preserves associative memory capacity with augmentation of dendrite ramification and spine generation in Tg2576 mice.

ABSTRACT: Alzheimer's disease (AD) is the most common neurodegenerative disorder and there is currently no efficient cure for this devastating disease. Cognitive stimulation can delay memory loss during aging and in patients with mild cognitive impairment. In 3 × Tg-AD mice, training decreased the neuropathologies with transient amelioration of memory decline. However, the neurobiological mechanisms underlying the learning-improved memory capacity are poorly understood. Here, we found in Tg2576 mice spatial training in Morris water maze (MWM) remarkably improved the subsequent associative memory acquisition detected by contextual fear conditioning. We also found that spatial training enhanced long term potentiation, dendrite ramification and spine generation in hippocampal dentate gyrus (DG) and CA1

SUBMITTER: Jiang X 

PROVIDER: S-EPMC4377552 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature