Yeast Phenomics: An Experimental Approach for Modeling Gene Interaction Networks that Buffer Disease.

ABSTRACT: The genome project increased appreciation of genetic complexity underlying disease phenotypes: many genes contribute each phenotype and each gene contributes multiple phenotypes. The aspiration of predicting common disease in individuals has evolved from seeking primary loci to marginal risk assignments based on many genes. Genetic interaction, defined as contributions to a phenotype that are dependent upon particular digenic allele combinations, could improve prediction of phenotype from complex genotype, but it is difficult to study in human populations. High throughput, systematic analysis of S. cerevisiae gene knockouts or knockdowns in the context of disease-relevant phenotypic perturbations provides a tractable experimental approach to derive gene interaction networks, in order to de

SUBMITTER: Hartman JL 

PROVIDER: S-EPMC4377832 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature